Wound healing
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Chronic wounds in diabetes mellitus and occlusive arterial disease
Oxygen
is essential in wound healing for process of collagen formation, epithelialisation
of the wound and immune defense. Differences of oxygen supply in ischemic and
neuropathic wounds and its effects on wound healing could be shown [1].
Local perfusion monitoring has the advantage of assessing healing potential
of wounds and diagnose infections in early stages.
Figure 1: Increase of local oxygen saturation two weeks before
infection of the wound. During infection sharp fall in oxygen saturation as
sign of increased oxygen extraction and further decrease of saturation during
healing of ulcer, as hyperemia decreases. (Schematic overview of results of
[1])
Literature:
O2C
Papers
- The
Impact of the Micro-Lightguide O2C for the Quantification of Tissue Ischemia
in Diabetic Foot Ulcers
S. Beckert, M. B. Witte, A. Königsrainer, S. Coerper; Diabetes Care 2004;
27, 2863-2867
- O2C relevant
data extracted from "The Impact of O2C for the Quantification of Tissue
Ischemia in Diabetic Foot Ulcers"
- Device
Measures Tissue Oxygenation at Wound Site; May Predict Difficult-to-Heal
Diabetic Foot Ulcers
J. Hendry; Potiatry-Online 2005
- NEW METHOD FOR
MEASUREMENT OF ISCHEMIA IN WOUNDS - A PILOT STUDY
Coerper S., Beckert S., Beckert H. D., Dept. of General Surgrey, University
Hospital, Tuebingen, Germany ; 6th World Congress on TRAUMA 2004
- NON-INVASIVE MEASUREMENTS
OF MICROCIRCULATION IN THE BURN WOUND
RENNEKAMPFF HO; PFAU M; MERZ K, SCHALLER HE, Dept of Hand and Plastic Surgery,
Burn Center, BG-Trauma Center, Univ. of Tuebingen ; 6th World Congress on
TRAUMA 2004
- Evaluation
des Mikrolichtleiters und Spektrophotometers (O2C) zur Erfassung und Quantifizierung
der Ischämie im Rahmen der Heilung ischämischer Wunden
S. Coerper, S. C. Wolf, H. D. Becker, Chirurgische Universitätsklinik,
Klinik für allgemeine Chirurgie, Tübingen Vasomed, Dezember 6
/ 03
- O2C relevant
data extracted from "O2C (oxygen to see) values typical/critical for
skin"
- O2C
relevant data extracted from "O2C (oxygen to see) investigation on
toe (D1), test of 50 mmHg perfusion pressure at angle"
- O2C
relevant data extracted from "Parameters of Microcirculation and Healing
Time of Burn Wounds"
Vorträge / Talks
- Microcirculation
of the sternum following harvesting of the left internal mammary artery
K Knobloch, Deutsche Gesellschaft für Thorax-, Herz und Gefässchirurgie,
Leipzig, 23.-26.02.2003
- Assessment
of microcirculation of the hand following harvesting of the radial artery
for coronary bypass surgery (Abstract)
- Poster
K Knobloch, Deutsche Gesellschaft für Thorax-, Herz und Gefässchirurgie,
Leipzig, 23.-26.02.2003
- Mikrozirkulationsparameter
und Heilungszeiten bei Brandwunden (Poster)
M.Pfau, Bergen, 2003
- Evaluation
des Mikrolichtleiters und Spektrophotometers (O2C) zur Erfassung und Quantifizierung
der Ischämie im Rahmen der Heilung ischämischer Wunden (Poster)
S. Coerper, Universitätsklinikum Tübingen, Klinik für Allgemeine
Chirurgie
- Non-invasive
Oxygen and Perfusion Monitoring (Abstract)
A.Krug, Hindsgavl, Denmark, 2002
Empho
Papers
- The
influence excerted by the temperature of the irrigation fluid on wound healing
Neander, Journal of Wound Healing, 2002
- Early
identification of diabetic foot ulcers that may require intervention
using the micro lightguide spectrophotometer.
S. M. Rajbhandari, N. D. Harris, S. Tesfaye, J. D. Ward;
Diabetes Care , 1999 Aug, 22(8):1292-5
- Lightguide
spectrophotometry for the assessment of skin healing viability in critical
limb ischaemia
DK Harrison, Adv Exp Med Biol 1995
- Microvascular
blood flow and oxygen supply in ulcerated skin of the lower limb
DJ Newton, Adv Exp Med Biol, 1995
- Oxygen
extraction rates in inflamed human skin using the tuberculin reaction as
a model
DJ Newton, Int J Microcirc Clin Exp, 1996
- Amputation
level assessment using lightguide spectrophotometry
DK Harrison, Prosthet Ortho Int, 1995
- O2C
relevant data extracted from "Amputation level assessment using lightguide
spectrophotometry"